Aimee Mann Lyrics and Gendered Language Patterns :: Free Essays Online

Aimee Mann Lyrics and Gendered Language Patterns Paul Thomas Anderson claims that many of the characters for his film Magnolia[1] were inspired by Aimee Mann lyrics and from knowing Aimee as a personal friend. As the film unfolds, the main theme of connectivity between the characters becomes apparent. If they are not connected in a physical way, they each are in a symbolic way linked as they deal with the necessity of love. Several times it is spoken in the film how someone has love to give, but does not know how to show it. The character Claudia, which Anderson said was played â€Å"with a true sense of Aimee Mann insanity†[2], is so desperate for love and to be needed; yet when Jim offers his love to her, she is so terrified that she runs from it. Here Anderson decides to not only refer to Aimee Mann, but actually has Claudia state to Jim a lyric from Aimee’s song â€Å"Deathly†: â€Å"Now that I’ve met you would you object to never seeing me again?†[3] As Claudia runs from the rest aurant it is clear that being needed in a relationship distresses her, the same emotion Aimee[4] reveals in her song lyric. As Anderson uses a song lyric as text in the film’s dialogue, the question of how lyrics can be looked at in terms of conversational content is raised. In showing how men and women speak differently Tannen cites many kinds of examples in You Just Don’t Understand. Not only does she look at experimental and observational studies, she also includes excerpts from plays and short stories to show that speech patterns carry over into artistic expression[5]. Lyrics then can be examined in this same manner though they are a different type of conversation. If a play is two or more characters conversing with one another on stage, a song lyric can be viewed as one side of a story of dialogue. It does not become any less conversational because of this, but is a different way to interpret a relationship. Deborah Tannen has achieved scholarly and public praise for her conclusions about how women and men differ in conversational styles. You Just Don’t Understand[6] clarifies stylistic differences in how the two sexes communicate with each other.

History of Electrocardiography Machine Essay

History of electrocardiography prevails over two centuries as an intellectual exercise as the process of inventing an electrocardiogram started with the Galvani’s idea of animal electricity. In 1842 this idea was further reinforced by Italian physicist Carlo Matteucci who illustrated by his experiments that electric current could be quantified from inactive heart muscle. German physiologist Emil Dubois-Reymond further explored this phenomenon and confirmed Carlo Matteucci’s conclusion and labeled this changing current in the resting muscle as â€Å"action potential†. He further developed a device that could deliver stimulation pulses to the muscles and was capable of computing discharge current of muscles at short intervals. In 1856 Rudolph von Koelliker and Heinrich Muller recorded an â€Å"action potentialâ€Å"on the spotaneous beating heart. But the major development came in 1872 when French physicist Gabriel Lippmann introduced a capillary electrometer. This capillary electrometer was based on the principle of â€Å"polarization† and â€Å"surface tension†. Structurally it was a slender glass tube with mercury-sulphuric acid base. The mercury meniscus stirred with the influx of electrical potential and was observable by a microscope. In 1893, Willem Einthoven who is considered as the inventor of modern electric cardiogram and its various principles used the term ‘electrocardiogram’ at a conference of the Dutch Medical Association. But major development occurred during the three years staring from 1901 when Einthoven dissatisfied with capillary electrometer and it slow response, designed a string galvanometer. This galvanometer contained a string eletromagnet to produce a magnetic flux, two piece poles, a quartz string between the two piece poles, peepholes in the two piece poles to observe the position of string. It further contained a lamp and timing systen to examine the shadow of string at different time intervals. The weight of this whole apparatus was about 600 pounds. He further modified the string galvanometer to invent a more effective electrocardiograms. However in 1902, Einthoven brought out the first electrocardiogram that was recorded on his string galvanometer. This was a giant’s leap in the history of bio-medical. In order to produce string galvanometer on commercial level, Einthoven discussed the possibilities with Horace Darwin of Cambridge Scientific Instruments Company of London. So this event made the electrocardiogram to come out of experimentation and to be used in medical profession. Einthoven, in 1906, circulated the first presentation electrocardiograms recorded with a string galvanometer. These electrocardiograms included the specimen of left and right ventricular and atrial, atrial flutter, ventricular premature beats etc. In 1910, Horatio Williams who was professor at Cornell University Medical College, New York issued electrocardiograms of patient that manifest atrial and ventricular ectopics, ventricular hypertrophy, atrial fibrillation and ventricular fibrillation that were recorded in hospital using a complex system of cables. This was first large-scale use of electrocardiograms in the hospitals. With the advent and introduction of vacuum tubes, the electric galvanometer was further modified and improved. In 1926, Ernestine and Levine used these vacuum tubes to produce enlarged images. Cathode rays tube further helped to produce portable electrocardiograms. Today electrocardiograms works on the same principles that were devised Einthoven in the first decade of 20th century. References Burchell HB. A centennial note on Waller and the first human electrocardiogram. Am J Cardiol 1987; 59:979-983 Burch, G.E. A History of Electrocardiography. Chicago. Year Book Medical. 1964. Burnett J. The origins of the electrocardiograph as a clinical instrument. Medical History Supplement 5: 1985, 53-76. Published as a monograph. The emergence of modern cardiology. Bynum WF, Lawrence C, Nutton V, eds. Wellcome Institute for the History of Medicine:1985. Fye WB. A history of the origin, evolution, and impact of electrocardiography. Am J Cardiol 1994;73:937-949 Plonsey, R. Bioelectric Phenomenon. New York. McGraw-Hill. 1972.

“How does Shakespeare present Macbeth as a disturbed character in Act 1 of Macbeth?” Essay

â€Å"How does Shakespeare present Macbeth as a disturbed character in Act 1 of Macbeth?† William Shakespeare wrote the play â€Å"Macbeth† in 1606. It, as the title suggests, follows the story of a Scotsman named Macbeth and how, after the prophecy of three witches, sees his status evolve from a general in the Kings army to becoming the King himself. However the main theme that Shakespeare introduces in this play is the lengths man will go to fulfil ambition and the treacherous consequences that come with it. Not only do we see Macbeth’s status evolve but also his personality within. With each scene we see Macbeth succumb to the pressures of achieving power and how this affects his character as well. Act 1 of â€Å"Macbeth† truly, from the beginning, shows us a clear development of Macbeth’s disturbed personality not only through language but the context behind this tragedy. In Act 1 Scene 2 we are not introduced to Macbeth, but not directly. Shakespeare describes him as a ruthless, violent but brave soldier through the mouths of admirers. When the Thane Ross and a Captain describe Macbeth’s â€Å"brave† performance during a victory over Norway, we are immediately acquainted to the respect that he is held in. The Captain describes him in a very positive manner, â€Å"For brave Macbeth – well he deserves that name† is a quote that clearly emphasises the admiration that fellow soldiers have for Macbeth. The use of the word â€Å"deserves† shows us that he has earned the right to be commended. However another interpretation of Macbeth’s heroics is possibly his ruthlessness. During his distinguishing, Macbeth is also described as quite a violent person. His fierceness is made apparent when the Captain conveys a very vivid explanation of how Macbeth killed a Norwegian, â€Å"Till he unseam’d him from the nave to the chaps†. This description is very daunting to think about and Shakespeare leaves this image implanted in the heads of the audience. The use of the word â€Å"unseam’d† shows us Macbeth’s ruthlessness when in battle, with possibly no respect for other’s lives. The violent aspect of Macbeth’s character can be interpreted a disturbed one. His ruthlessness is quite inhumane in the sense that he shows signs of a villainous character. Another way in which Macbeth is seen a disturbed character, is his association and connection with the three witches. When Macbeth and Banquo are introduced in Scene 3, Macbeth’s first line is â€Å"So foul and fair a day I have not seen†. This quote echoes the witches’ in Scene 1, â€Å"Fair is foul and foul is fair†. The phrase is almost a paradox, it can interpreted to show how nothing is as it seems. However the fact that Macbeth repeated a phrase said by witches all but adds to a negative insight into his character. During Shakespeare’s time, witches were seen as very real creatures. In the early 17th century, suspected witches were burnt and there was even an Act of Parliament put forward in 1604 against them. This was because witches were subjects of morbid and fevered fascination by society at this time; people feared them. They were seen as creatures of Satan and therefore evil characters. The use of the three witches in the play adds to the fear within it and with this, the use of Macbeth echoing their words adds to the sheer disturbance. During this time, Macbeth’s reference to â€Å"foul and fair† would have caused a negative impact on the way the audience looked at him. To be associated with repelled evil witches creates a dark atmosphere and tone throughout the play. After the witches’ prophecy, Macbeth’s mind is beginning to turn into a state of madness and paranoia due his constant change in thoughts. The ideas that roam Macbeth’s head prove to be a substantial part of the Act. The prophecy, which promises the status of King in the future, has been fixed into Macbeth’s mind, provoking ill thoughts. After bearing witness to the supernatural occurrence, Macbeth begins to contemplate the idea of kill the present King Duncan in order to become King. â€Å"This supernatural soliciting/Cannot be ill, cannot be good† is a quote that clearly shows us the mindset that Macbeth is in confusion. The use of the words â€Å"ill† and â€Å"good† makes it clear that he is between the two thoughts and his mind isn’t thinking straight however he comes to a conclusion that he shouldn’t intervene to make the prophecy become true. However Macbeth again contemplates the idea later on in Scene 4. After realising that Malcolm, Duncan’s Son, is the rightful heir to the throne, Macbeth is again mystified to whether he should intervene in fate. â€Å"The eye wink at the hand; yet let that be/Which the eye fears, when it is done, to see† illustrates his desire for power but reluctance to commit murder, â€Å"the eye fears†. The theme of hesitation and constant contemplation of Macbeth is a sign of confusion within his mind. This is a sign of a disturbed character. Another way in which Macbeth can be seen in a negative way is through his motives and if they are with foundation especially through eyes of the audience who witnessed â€Å"Macbeth† in William Shakespeare’s time. This includes the idea of treason and how power was a God given right. In Scene 7 we find that Macbeth is considering whether killing Duncan is the right act to commit due to the high respect that the King holds him in. When talking in his soliloquy (something that Shakespeare uses to shows the audience the thoughts and true feelings of characters) Macbeth talks about his respect for Duncan, â€Å"I am his kinsman and his subject†, this supports the fact that he is also related to Duncan and a trusted figure. However his mindset is yet again changed as he finally decides that murder is the best option, â€Å"Fal se face must hide what the false heart doth know† is a signal of his change of mind but, with that, his personality. The idea of Macbeth committing murder on a King would have been frowned upon when the audience of the 17th century watched â€Å"Macbeth†. Political connotations such as the Gunpowder Plot 0f 1605 was possibly used by Shakespeare to relate to Macbeth and the idea of killing Kings. â€Å"Macbeth† was possibly used as a caution against potential regicides, especially with the patron of Shakespeare’s productions being the King James. Also religious connotations, such as the idea that the status of King was a God given right, played a significant part. Macbeth is aspiring to achieve a status that isn’t a God given thing, especially at this time the theme of treason was heavily frowned upon. The idea of Macbeth wanting to achieve Kingship without God given rights would have added to his disturbing character. There are other examples that show Macbeth’s disturbed character. One other factor could be his irrational thinking and the way that Lady Macbeth must always intervene to make him think right. Near the end of Scene 7, Macbeth tell his wife that he will not commit the murder, â€Å"We will proceed no further in this business†, is a firm claim from Macbeth. His tone is one that is very decisive however after the persuasive techniques of Lady Macbeth he quickly changes his mind. â€Å"I am settled, and bend up/ each corporal agent to this terrible feat† is said at the end of the scene, showing Macbeth’s sudden change in mind and sheer willingness to kill King Duncan. Macbeth doesn’t think straight and can be seen as having a fragile mind, one that can be easily moulded. Overall, Shakespeare successfully shows the audience how Macbeth develops his disturbed character. By using language features and also the views of certain themes of the audience of the time, he introduces a very irrational character. These themes include violence, religion, politics and the idea that man’s desire for power outweighs any respect for the consequences. Macbeth slowly develops from a violent person to someone who is very fragile in the mind and also, essentially, a disturbed character.

Cancer Diary of Osteosarcoma

SUBMITTED BY: ARAGAW GEBEYEHU SUBMITTED: DR. FLORES ROZAS DATE OF SUBMISSION: 04/16/1801/26/12 My name is osteosarcoma. I am highly malignant tumor of mesenchymal origin and the second most common primary malignant bone tumor .I am originate from mesenchymal cells. I have spindle shape and hyper chromatic nucleus. I have been formed when osteoblasts cells secreted malignant osteoid. I am like osteoblast (bone forming) cells, but I cannot make strong matrix like them. You know that osteoblasts originate from immature mesenchymal stem cells. So my ancestors are from those. But I am already modified in to osteosarcoma cell. I can occur at any bones found in the body. I am more frequent at sites of the most rapid bone growth; those are extremities of long bones near metaphyseal growth plates. From the sites that I frequently choose ;distal and proximal end of femur (42%),proximal end of tibia(19%), proximal end of humerus (10%), pelvis skull and jaw(85%) and pelvis( 8%). I can be appearing 1 to 3 million people per year. Off course, I am rare compared to other types of cancer. I can attack any age as primary osteosarcoma but mostly between 10-25yrs. I can also come at older individuals as secondary osteosarcoma. I affect males little bit more than females. I am most common in patients with Fraumeni syndrome, Rothmund-Thomson syndrome, Bloom and Werner syndromes. Exposing to Paget disease and ionizing radiation give favorable conditions for me to develop our colony. Fig 1. Osteosarcoma genesis and osteogenesis When I was changing to osteosarcoma, there was a mutations of MDM2 amplifications which led to p53 gene inactivation. Another controller gen which is called retinoblastoma (RB) genes was also altered. I become safe because there is no more check point and control for me .But the normal bone cells have several check points in their cell cycle. In the presence of RB mutations I will occur at an incidence 500 times that of the normal population. Normal cells are always worrying for G1/S check point but I am not, because the p53 and Rb genes are already mutated (lost their function). I am preparing more DNA and for that I am also synthesizing mRNA and important proteins. During my replication time I gained chromosome number 1 and lost chromosome 9, 10 and 13. Till now I am successfully dividing and I am forming other similar cells. In near future I will have my own colony of cells and my own sarcoma tissues01//14/2014As usual I was preparing to divide but the proteins detected a damage in my DNA. The damage was too big to be repaired. Even if it is bigger damage I will not go to programmed cell death called apoptosis. Because this is not my character. My only goal is to survive and proliferate more. This is my unique behavior. Of course I was not like this, I was following the normal path of cell cycle and programed cell death. This thing happened after I lost my DNA sequence that triggers cell death pathway.5/18/15Recently I got another mutations and my FOS and Jun proteins are up regulated. Those proteins are components of activator protein1 complex (AP-1). AP-1 his regulator of cell transcription. Now I am getting additional energy because my transcription regulators are out of service. I can proliferate freely and destroy bone cortex and extend towards bone marrow cavity and soon out wards towards adjacent soft tissues.10/17/15I am now thinking why not I visit other organs. I have information lung, liver and also other bones are the safe place and more fertile to me . When I become more organize, I can migrate and live there. I am already resistant to programed cell death (anoikis) and can exhibit anchorage independent growth (AIG). Abnormal integrin? v6, Rho, ATPase e.g. Racl and Cdc42 upregulated p13 kinases which in turn inhibited proapoptotic factor Bad and this protected me from apoptosis even when I am not attached to any membrane. Now I have bigger size with hypoxic and acidic environment. So I need supporting blood vessels to obtain oxygen and nutrients I have done angiogenesis for my sustained growth and further metastasis. My intrinsic conditions have to lead to stimulation of von Hippie Lindau protein. It releases hypoxia inducible factor-1? (HIF-?)which further up regulates several VEGF gene such as VEGF A through VEGF E. This further releases Nitric oxide (NO) from endothelial cells and results in vasodilation and increased vascular permeability. By doing those processes I got leaky and irregular vasculature.3/14/16 I am starting flight to lung. I am using integrin proteins, which found in my surface ,in attaching to matrix proteins (fibronectin).For my signal transduction and interaction with other cells, I use integrin along with ezrin protein ,foal adhesion kinase (FAK),protein kinase C (PKC) and Rho GTPase. They also help me for my conformational changes. Besides to this matrix metalloproteinase (MMPs) are helping me in my sojourn through blood vessels and tissue renewal process. Now I have reached the lungs and I am growing, multiplying and consuming all nutrients. It is like as I heard .I like it.10/10/2016Today, the patient could not resist me .He took me to hospital. Because I create sever pain and swelling. I was diagnosed by radiograph as high grade sarcoma. Additionally they did CT scan, RI and biopsy and confirmed my stage. They are now discussing to fight against me.Yes they have started chemotherapy (high dose methotrexate, doxorubicin and cisplatin). I have been fighting against those drugs for the last three months and I am now getting old, starving and feeling weaker day by day. Oh those drugs become treble for me. Methotrexate is a dihydrofolate reductase inhibitor, it can block folic acid supply which is needed for my RNA and DNA synthesis. Doxorubicin which is also a drug that interact with my DNA and inhibits biosynthesis of macro molecules. Cisplatin causes damage to my DNA. I have to create solutions, because I am no longer able to make RNA efficiently. But I am struggling to continue my life. I got another mutations which is alteration in reduced folate reductase (RFC) protein Leu291pro.Yes I did it. This alteration unable carrier to transport methotrexate towards me .Besides to this, membrane pump-glycoproteins (P-gp) is also helping me with pumping out these drugs. Due to this I start dividing and spreading slowly but steadily. Other worse situations are happening to me, they are using high energy rays (x-rays) to kill me. I am no longer able to grow. I am shrinking. 4/14/18The worst thing are happened on me. Now, they are performing surgery and removing me as cancerous tissue. I was sending my daughters to afar to lung. By myself I am highly depressed and weak due to huge loss my colony. I try to grow and spread again by my reserve soldiers and by those immigrant members. They are still in dilemma to administer chemotherapeutic agent after surgery. The people are always struggling to combat me and other friends. If they post-surgery chemotherapy no more survival .I say good bye I will not be there anymore. REFERENCEBiomarkers in osteosarcoma, Colin Kong, M.S and Marc F. Hansen, Ph.D.Biology and therapeutic advances in pediatric osteosarcoma, Nayssa Marina Et.al,The oncologist ,2003Novel therapeutic strategy for osteosarcoma targeting osteoclast differenciation, bone reabsorbing activity ,and apoptosis pathways.The molecular pathogenesis of Osteosarcoma; A review, Matthew L. broadhead, sarcoma, 2011.Current strategy for chemotherapy in Osteosarcoma, Dorothy carric, International Orthopedics, 2006Osteosarcoma: A review of diagnosis ,management and treatment strategies, David S. geller ,MD, and Richard Gorlic MDSwitch from ?v?5 to ?v?6 integrin expression protects squamous cell carcinomas from anoikis, S.M. Janes ,Journal of cell Biology,2006.Analysis of molecular mechanisms of osteosarcoma using bioinformatics approach ,Jaxon yang ,oncology letters,2016.

Personal plan in engaging cultural competence in Nursing Essay

Personal plan in engaging cultural competence in Nursing - Essay Example lways unavailable due to a busy schedule and family members of the patient were only able to speak with the nurses-on-duty at night, who were mostly Koreans or Chinese. One staff-on-duty just migrated from Korea and had limited English. Two days after the admission to the hospital, the patient died on her sleep. The cause of death was unknown, but the doctor implied that she may have had a heart attack that night. It was the only time, the day when the patient died, when the family was finally able to speak with the doctor who had been in a very busy schedule when the patient was still alive. I was really devastated when I found out that my grandmother died. I was not able to visit her when she was in the hospital; it was all so abrupt for the family. It was indeed a quick turnaround. She was healthy days before being admitted to the hospital, and she was always on schedule with her doctor and was equipped with her medication prescriptions, until her sudden death. My family and relatives all questioned her sudden demise. Indeed, there were symptoms, but these were not addressed properly, leading to her immediate death. For several years now, I have been thinking that her death was primarily prompted by lack of communication with the physician and the medical staff, and one major reason of which I believe, was language barrier and cultural diversity between my grandmother and her family on one hand, and the medical staff and the primary physician on the other hand. Another thing was that my grandmother was someone who tended to agree on everything from a healthcare staff even if she thought otherwise. One common trait among Filipinos is being reserved in many ways, such that we do not argue or debate to point out our views. With the diversity of culture, religion, and ethnicity of patients, medical staff, and other networks of the hospital in the healthcare field, it is important that communication is ensured in the way that each individual understands one

OLI model Essay Example | Topics and Well Written Essays - 3000 words

OLI model - Essay Example The above approach neglects critical issues, which are critical in defining a multinational firm. The model has three areas where its main advantages are based, that is; It has its advantages in explaining the MNEs existence. Ownership has its advantages in the sense that it addresses the question of why that some firms will go abroad and not others, it postulates that there are some benefits that allow it to overpower the cost of operating abroad. Since firms are the collection of different assets and MNEs candidate has a higher-than-average asset level to have an internal public goods character. The assets can be used in the production in various areas without reduction of their effectiveness. The assets include product dimensional factor, common to model in terms of a single index of the production of the firm. The highest sophisticated treatment in these lines is found in immediate work on non-homogeneous firms that combines the horizontal simplest version motive for FDI, with an assumption of their productivity differences (Faeth, 2009). The OLI model has an aspect to pay a sunk cost in productivity determination. Low-production can be produced only for the purposes of the home market; while medium productivity ones are chosen to pay for export fixed costs, but the most productive ones chosen to pay for higher costs for FDI engagements. The above predictions are in accordance with the evidence. On a further contribution, the model provides that industries with greater heterogeneities have more firms engaged in the FDI. Location advantages address the question of where the firm chooses to locate. Though the theory of international trade has taken ownership advantages just for granted, to make them in more obvious ways, this model has emphasized more on exploration of alternative motives to be located by MNEs abroad. The major factor that has created much attention is the clear distinction between vertical and horizontal FDI. Horizontal FDI happens when

Episcopal Social Services Essay Example | Topics and Well Written Essays - 1000 words

Episcopal Social Services - Essay Example From its humble beginnings of providing assistance to needy immigrants in New York, ESS has expanded its activities to take on several social activities, starting with children and going on to adolescents requiring support and then on to adults. At the heart of the social activities lies the theme of improving the capabilities of individuals to become productive members of society and improve the quality of their life. This paper describes Episcopal Social Services and its activities as a social service organization. This paper has been written after visiting Episcopal Social Services, 305, Seventh Avenue, New York and collecting information from Naomi Hopkins, their Communication Manager. ESS was founded in 1831 by members of the Episcopal Church, in an attempt to assist the vast number of immigrants arriving in America to overcome their difficulties. Though it had a religious background ESS from its founding days remained non-sectarian as it reached out any person that was poor, sick, homeless, hungry, or imprisoned to provide the needed service (Episcopal Social Services, 2011). Throughout its 180 years of existence ESS has maintained this mission of attempting to transform and better the lives of the disadvantaged and needy residents of New York City (Episcopal Social Services, 2011). These services cover children, families and children. As early as 1864 ESS reached to provide convalescent homes and summer camps for the infirm and the undernourished; temporary lodging; clothing, food, and emergency funding for the destitute; trade schools for developing skills in the unskilled; and social clubs and free reading rooms to help keep poor people off the rough and dang erous streets of New York (Episcopal Social Services, 2011). Expanding their activities, ESS in 1907, set up an office at Ellis Island for the purpose of providing assistance to newly arrived immigrants, who were quarantined